Dermatitis herpetiformis, the celiac disease of the skin!
نویسنده
چکیده
Gluten-related diseases were recently classified into three groups according to their physiopathological mechanisms: autoimmunity (celiac disease, dermatitis herpetiformis, gluten ataxia), allergy (wheat allergyrespiratory, alimentary, contact urticary and WDEIA) and no-autoimmune no-allergic (gluten sensitivity)(30). Dermatitis herpetiformis (DH) is an autoimmune blistering cutaneous disease that appears as a consequence of gluten intolerance. There is evidence that DH should be considered as the specific phenotypic cutaneous expression of a gluten-sensitive enteropathy indistinguishable from celiac disease (CD)(36). Immunological studies demonstrated the presence of granular deposits of IgA along the dermal-epidermal junction(32). DERMATITIS HERPETIFORMIS, THE CELIAC DISEASE OF THE SKIN!
منابع مشابه
Dermatitis Herpetiformis: From the Genetics to the Development of Skin Lesions
Dermatitis herpetiformis (DH) is a rare autoimmune disease linked to gluten sensitivity with a chronic-relapsing course. It is currently considered to be the specific cutaneous manifestation of celiac disease (CD). Both conditions are mediated by the IgA class of autoantibodies, and the diagnosis of DH is dependent on the detection of granular deposits of IgA in the skin. There is an underlying...
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Gluten sensitivity typically presents as celiac disease, a common chronic small intestinal disorder. However, in certain individuals it is associated with dermatitis herpetiformis, a blistering skin disease characterized by granular IgA deposits in the papillary dermis. While tissue transglutaminase has been implicated as the major autoantigen of gluten sensitive disease, there has been no expl...
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Dermatitis herpetiformis (DH) is an inflammatory cutaneous disease with a chronic relapsing course, pruritic polymorphic lesions, and typical histopathological and immunopathological findings. According to several evidences, DH is considered the specific cutaneous manifestation of celiac disease, and the most recent guidelines of celiac disease have stated that, in celiac patients with a proven...
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ورودعنوان ژورنال:
- Arquivos de gastroenterologia
دوره 50 3 شماره
صفحات -
تاریخ انتشار 2013